Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AKAP7 contributors: mct - updated : 20-11-2013
HGNC name a kinase (PRKA) anchor protein 7
HGNC id 377
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central domain that may act as a phosphoesterase, binding AMP
  • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text in both the nucleus and cytoplasm of oocytes
    basic FUNCTION
  • A kinase (PRKA regulatory subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • potentially involved in L-type calcium ion channel activation
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AKAP7 interacts with neuronal CACNA1C via their C terminus
  • interaction between the ubiquitous enzyme PKC (protein kinase C) and the scaffolding protein AKAP7 (AKAP7 could play an integral role in dictating PKC localization and function in tissues where the two proteins are co-expressed)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS