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FLASH GENE
Symbol ZHX1 contributors: mct - updated : 26-05-2020
HGNC name zinc-fingers and homeoboxes 1
HGNC id 12871
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal zinc fingers
  • five central and C-terminal homeo (helix-turn-helix) domains
  • a C-terminal acidic region and two putative nuclear localization signals
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Zhx1
    intraspecies paralog to ZHX3
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional repressor
  • may play like a bridging molecule between DNMT3B
  • and other co-repressor protein
  • enhancing the transcriptional repression mediated by DNMT3B when DNMT3B is directly targeted to DNA
  • ZHX1, ZHX2, ZHX3 have biological roles in cell cycle control by acting as co-repressors of the transcriptional regulator Nuclear Factor Y
  • nuclear transcription repressor known to be involved in cell differentiation and tumorigenesis
  • plays crucial roles in the progression of glioblastoma
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms heterodimers with ZHX3 which is a prerequisite for repressor activity and with ZHX2
  • universal repressor complex containing DNMT3B and
  • ZHX1
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding to the nuclear transcription factor NF-Y
  • interacting with NFYA
  • homeobox domains of ZHX1 interact with the PWWP
  • domain of DNMT3B
  • ZHX1 interact with the activation domain of the nuclear factor Y subunit A (NFYA) and to have a transcriptional repression activity
  • could contribute to glioblastoma progression via the regulations of TWIST1 and SNAI2
  • podocyte ZHX2 imbalance is a critical factor in glomerular disease, with minimal change disease disparities mediated mostly through ZHX1, and focal segmental glomerulosclerosis deviations through ZHX3 and ZHX2
  • cell & other
    REGULATION
    Other SUMOylation of ZHX1 regulated the stability, ubiquitination and transcriptional activity of ZHX1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in clear cell Renal cell carcinoma (RCC), associated with poorer survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • it is an independent prognostic marker in clear cell Renal Cell Carcinoma (ccRCC)
  • potential prognostic maker of glioblastoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    as a potential target for the treatment of Cholangiocarcinoma
    cancerbrain 
    therapeutic target of glioblastoma
    ANIMAL & CELL MODELS