basic FUNCTION
| Kunitz-type serine-protease inhibitor, potent inhibitor of a number of serine proteases involved in blood coagulation and fibrinolysis such as pancreatic trypsin, plasmin, kallikrein-11 and hepatocyte growth factor activator |
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playing an important regulatory role in pericellular activation of hepatocyte growth factor/scatter factor (HGF/SF), critically involved in the development and regeneration of various tissues |
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may play a role in the process of spermatogenesis |
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may regulate ST14 activity |
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SPINT1, SPINT2 influence proliferation and cell fate of |
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neural progenitor cells (NPCs) and their expression levels are linked to BMP signaling |
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imbalance between SPINT2 and ST14 expression led to ST14 activation, thereby increasing cell migration, invasion, tumorigenicity and metastasis |
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SPINT1 regulates the activity of activated ST14, whereas SPINT2 has an essential role in regulating PRSS8-dependent ST14 zymogen activation |
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is associated with tumor-suppressive functions in melanoma by inhibiting an extracellular signal regulator of HGF, which is typically activated by tumor-stromal interactions |
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involvement of SPINT2 in Prostate carcinoma tumorigenesis, probably in association with a post-translational regulation of SPINT2 |
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is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFAC, hepsin and ST14 |
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inhibits proteases involved in activation of both influenza viruses and metapneumoviruses |