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FLASH GENE
Symbol MAN1A2 contributors: mlc/np - updated : 02-11-2007
HGNC name mannosidase, alpha, class 1A, member 2
HGNC id 6822
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic tail
  • a single transmembrane segment (TM1)
  • a large COOH-terminal catalytic domain
  • a potential N glycosylation site
    • HOMOLOGY
    interspecies homolog to murine alpha1.2 Mannosidase 13
    Homologene
    FAMILY glycosyl hydrolase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • involved in processing of Asp-linked (N) glycans
  • involved in hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the oligo-mannose oligosaccharide
    • Man(9)(GlcNAc)(2)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    Ca2+
    protein
    cell & other
    REGULATION
    inhibited by both 1-deoxymannojirimycin and kifunensine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS