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FLASH GENE
Symbol RCAN2 contributors: mct - updated : 22-02-2008
HGNC name regulator of calcineurin 2
HGNC id 3041
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RNA recognition motif (RNA-binding protein)
  • a short unique serine-proline motif (the FLISPP signature of the family) including an ISPP XSPP box
  • a Cn-inhibitor RCAN (CIC) and the PxIxxT motifs (Mulero 2007)
  • bind and inhibit Calcineurin through the C-terminal region (Mulero 2007)
  • secondary structure beta/alpha
    HOMOLOGY
    interspecies ortholog to hamster Adapt 78
    homolog to Drosophila melanogaster
    homolog to C.elegans
    homolog to yeast S.pombe
    homolog to yeast S.cerevisiae
    intraspecies paralog to RCAN1, DSCR1L2
    Homologene
    FAMILY MCIP family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • putative regulator of calcineurin-mediated signaling pathway
  • potently activates angiogenesis and could be an attractive target for antiangiogenesis therapy
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein calcineurin A, PPP3CA, PPP3CB, PPP3CC
    cell & other
    REGULATION
    induced by thyroid hormone-responsive gene,triiodothyronine (T3)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    induced the proliferation and activation of the transcription factor NFAT in cultured endothelial cells and promoted angiogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target attractive target for antiangiogenesis therapy
    ANIMAL & CELL MODELS