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FLASH GENE
Symbol LAMC3 contributors: mct - updated : 28-03-2012
HGNC name laminin, gamma 3
HGNC id 6494
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 19 amino acids signal peptide (1.8 kDa)
  • four laminin A/neurexin/sex hormone-binding (LNS) globular domains separated by multiple EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI), and a long arm composed of heptad repeats typical of an cell alpha helical coiled-coil protein
  • secondary structure three non identical chains A, B1, B2 (alpha, beta, gamma)
    conjugated GlycoP
    mono polymer heteromer , trimer
    isoforms Precursor a 1568 amino acids mature peptide (130.3 kDa)
    HOMOLOGY
    interspecies homolog to rattus Lamc3 (76.09 pc)
    homolog to murine Lamc3 (75.53 pc)
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • extracellular matrix
  • apical membrane
  • basic FUNCTION
  • involved in development and stabilization of epithelial structures
  • unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains
  • extracellular cell adhesion molecule localizing to basement membranes and essential for early embryonic development
  • role for LAMC3 in extracellular matrix organization of the somatodendritic compartment
  • CELLULAR PROCESS cell life, differentiation
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of cutaneous basement membrane zone
  • heterotrimerizing with Alpha and BÍta subunits, forming laminin 12, laminin 13 and laminin 15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OCGA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    sporadic autistic disorder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS