basic FUNCTION
| potential effector for CDC42, may be involved in cell morphology |
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exist as one component of a multifunctional scaffolding complex comprising IQGAP1, beta-catenin, and E-cadherin, with no evidence for direct IQGAP1-IQGAP2 interactions |
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novel tumor suppressor gene specifically linked to the development of hepatocellular carcinoma and the activation of the Wnt/beta-catenin signaling pathway |
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silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development |
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IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor |
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IQGAP2 and AKAP11 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton |
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IQGAP1, -2, and -3, are involved in diverse ranges of cellular processes such as adhesion and migration |
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is a RHO-GTPase binding protein, highly abundant in podocytes, which controls normal podocyte structure and function |
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inhibited ovarian cancer cell epithelial-mesenchymal transition, migration and invasion via suppression of Wnt-induced CTNNB1 nuclear translocation and transcriptional activity |
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tumor suppressor predominantly expressed in the liver, is a novel gene putatively required for IFN antiviral response against hepatitis C virus (HCV) infection |
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involvement of IQGAP2 in regulating IFN-stimulated genes (ISG) induction by IFN in an NFKB1-dependent manner |