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FLASH GENE
Symbol SYCP2 contributors: mct/npt - updated : 14-01-2020
HGNC name synaptonemal complex protein 2
HGNC id 11490
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 14S/T-P and 36S/T-S/T motifs putatively involved in DNA binding
  • two potential p34cdc2 (CDC2) target sites
  • two nuclear localization signals (NLS)
  • multiple potential DNA binding motifs
  • a C terminal potential coiled-coil structure, interacting with SYCP3
  • HOMOLOGY
    interspecies homolog to murine Scp2
    intraspecies paralog to SYCP2L
    Homologene
    FAMILY
  • SYCP2 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the structural organization of meiotic prophase chromosomes
  • required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division
  • acts as a linker between SYCP1 and SYCP3 and therefore would be the missing connecting link between lateral elements and transverse filaments essential for proper chromosome synapsis (Winkel 2009)
  • SYCP2 may act as a bridge that brings the Synaptonemal complex and centromere together
  • SYCP3 and the SYCP2 C terminus, form a compact core around which cohesin complexes, HORMADs, HORMAD1, and HORMAD2 and the N terminus of SYCP2 are arrayed
  • role of SYCP2 in human male fertility
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of synaptonemal complex protein 2, axial element
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • SYCP2 interacting with SCYP3 (associate with the centromere regions of male, but not female, metaphase-I chromosomes, suggesting a sex-specific function for the two proteins)
  • SYCP2 N-reminal region interacts with the centromere during meiosis I, with CENPJ and CENPF
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF41
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking the Sycp2 coiled-coil domain also have an infertility phenotype