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FLASH GENE
Symbol TMEM59 contributors: shn - updated : 31-01-2011
HGNC name transmembrane protein 59
HGNC id 1239
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a minimal 19-AA peptide in its intracellular domain that promotes LC3 labelling and lysosomal targeting of its own endosomal compartment, and may facilitate the search for adaptor proteins that promote selective autophagy by engaging ATG16L1
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Tmem59, Mus musculus
    ortholog to TMEM59, Pan troglodytes
    ortholog to Tmem59, Rattus norvegicus
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • a modulator of amyloid precursor protein shedding
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with ATG16L1 and mediates autophagy in response to Staphylococcus aureus infection
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS