Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PMPCB

contributors: mct - updated : 16-05-2018

HGNC name	peptidase (mitochondrial processing) beta
HGNC id	9119

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

zinc binding region

conjugated

PhosphoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY	insulinase family
	peptidase M16 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	acting as a mitochondrial processing peptidase
	catalytic subunit cleaving presequences from mitochondrial protein precursors
	catalytic subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

text	involved in transit peptide

PATHWAY

metabolism

signaling

a component

heterodimer of alpha and beta subunits

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+ (per subunit)

protein	mitochondrial processing peptidase PMPCB generates an intermediate form of AFG3L2 that is matured autocatalytically
	new role for PMPCB in PINK1 import and mitochondrial quality control via the PINK1–Parkin pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MMDS6

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS