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FLASH GENE
Symbol MYBPH contributors: mct - updated : 21-05-2012
HGNC name myosin binding protein H
HGNC id 7552
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two immunoglobulin-like C2-type domains
  • two fibronectin type III domains, and one fibronectin type III domain was required for MYBPH binding to MYH9
  • HOMOLOGY
    interspecies ortholog to murine Mybph
    homolog to rattus Mybph
    homolog to zebrafish Dr.7502
    homolog to C.elegans T06D4.1
    Homologene
    FAMILY
  • immunoglobulin superfamily, MYBP subfamily
  • CATEGORY adhesion , motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the regulation of striated muscle contraction
  • may be involved in interaction with thick myofilaments in the a-band
  • MYBPH is a transcriptional target of the TTF1 lineage-survival oncogene and plays a crucial role in inhibition of cancer cell motility, invasion, and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • structural constituent of muscle
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to myosin and to thick myofilaments in the A-band
  • MYBPH directly interacts with an additional molecule, MYH9, which was found to occur between MYBPH and the rod portion of MYH9
  • MYBPH inhibited MYH9 assembly and reduced cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS