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FLASH GENE
Symbol PRKRIR contributors: mct - updated : 30-08-2012
HGNC name protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
HGNC id 9440
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a THAP domain, a zinc-dependent sequence-specific DNA-binding domain belonging to the zinc-finger superfamily
  • C-terminal domain required for physical interaction and the signal augmentation
  • HOMOLOGY
    intraspecies homolog to HSP (90kDa)
    Homologene
    FAMILY PRK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • protein kinase,double stranded RNA dependent inhibitor,particularly of P58
  • may function as zinc-dependent sequence-specific DNA-binding factors with roles in proliferation, apoptosis, cell cycle, chromosome segregation, chromatin modification, and transcriptional
  • synergistically enhances type I IFN production mediated by a signal activated- or constitutively active form of regulation of DDX58
  • novel positive regulator controlling the DDX58-IFN production system through protein stability control
  • inhibits ubiquitination of DDX58 and suppresses proteasomal degradation of DDX58 proteins, thereby enhancing DDX58-mediated signaling pathways for IFNB synthesis
  • novel positive regulator of DDX58-mediated antiviral signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DDX58 interacting protein (DDX58 interacts through the C-terminal domain of PRKRIR, and the N-terminal region of PRKRIR potentially possesses inhibitory functions to block DDX58 interaction)
  • selectively acts on the DDX58-mediated IRF3 activation and type I IFN synthesis, but not IFIH1
  • cell & other
    REGULATION
    induced by interferon-inducible
    in the virus-infected cells through NLRC5 activation, and controlling the activity of the antiviral protein PKR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS