basic FUNCTION
| chemokine receptor, directing B cell migration to defined lymphoid organs and spleen |
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required for normal development of secondary lymphoid tissue |
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plays a role in chronic lymphocytic leukemia cell (CLL) positioning and cognate interactions between CLL and CXCL13-secreting CD68+ accessory cells in lymphoid tissues |
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activating Ca2+ signaling and chemotaxis independently of inhibitory G proteins |
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maintaining B and T cell infiltrates and ectopic follicles in thyroid tissue from patients with autoimmune diseases |
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may participate in the establishment of B-cell dysfunctions during HIV-1 infection |