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FLASH GENE
Symbol CXCR5 contributors: mct/npt/pgu - updated : 13-01-2010
HGNC name chemokine (C-X-C motif) receptor 5
HGNC id 1060
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments receptor
  • HOMOLOGY
    interspecies homolog to murine Blr1
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • chemokine receptor, directing B cell migration to defined lymphoid organs and spleen
  • required for normal development of secondary lymphoid tissue
  • plays a role in chronic lymphocytic leukemia cell (CLL) positioning and cognate interactions between CLL and CXCL13-secreting CD68+ accessory cells in lymphoid tissues
  • activating Ca2+ signaling and chemotaxis independently of inhibitory G proteins
  • maintaining B and T cell infiltrates and ectopic follicles in thyroid tissue from patients with autoimmune diseases
  • may participate in the establishment of B-cell dysfunctions during HIV-1 infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • CXCL13/CXCR5 signaling effect on shaping B-cell dynamics is an effective mechanism that enhances antigen encounter and BCR-triggered B-cell activation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand CXCL13 (mediated chemotaxis of neuroblasts in response to CXCL13)
  • interacting with GRB2 (specifically controls a branch of CXCR5 signaling in B cells that induces lymphotoxin beta transcription but not chemotaxis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with its ligand, CXCL13 in B-cell chronic lymphocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS