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FLASH GENE
Symbol LDOC1 contributors: mct - updated : 05-12-2011
HGNC name leucine zipper, down-regulated in cancer 1
HGNC id 6548
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • leucine zipper-like motif at the N terminal
  • a proline-rich region (marked similarity to a SH3 binding domain)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a possible role in transcriptional regulation
  • product may have an important role in the development and/or progression of some cancers
  • regulator of the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB)
  • may play a role in normal B-cell development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with MZF1 (enhancing the activity of LDOC1 for inducing apoptosis)
  • binds directly to the verprolin homology domain of WASF3
  • cell & other
    REGULATION
    inhibited by negatively regulated by WASF3
    Other down-regulated in some cancer cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in some cancer cell lines(in pancreatic cancer)
    constitutional     --over  
    caused externalization of the cell membrane phosphatidylserine, which was characteristic for early-phase apoptotic events, and reduced cell viability in some human cell lines
    tumoral     --low  
    dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LDOC1 mRNA expression is an excellent predictor of overall survival in untreated chronic lymphocytic leukemia patients
  • Therapy target
    ANIMAL & CELL MODELS