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FLASH GENE
Symbol GNAL contributors: mct/npt - updated : 03-01-2017
HGNC name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
HGNC id 4388
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase domain made of three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • G-alpha family
  • G(s) subfamily
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • alpha stimulating activity, olfactory type
  • involved as modulators or transducers in various transmembrane signaling systems
  • may be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters
  • GNAL-encoded protein is important for dopamine D1 receptor function and odorant signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteromeric G protein complex, with 3units: alpha, beta and gamma
  • the alpha chain contains the guanine nucleotide binding site
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DYT25
    Susceptibility
  • to bipolar disorder and schizophrenia
  • possible contribution in the susceptibility to ADHD, with possible involvement of parent-of-origin effects (Laurin 2008)
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS