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FLASH GENE
Symbol USP33 contributors: mct/npt - updated : 13-03-2018
HGNC name ubiquitin specific peptidase 33
HGNC id 20059
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ZnF UBP domain
  • a protein module found in many proteins in the ubiquitin-proteasome system, that does not bind to ubiquitin (Allen 2007)
  • HOMOLOGY
    interspecies homolog to murine Vdu1
    Homologene
    FAMILY
  • peptidase C19 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • would be involved in ubiquitin-dependent protein catabolism
  • deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein and also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase (Allen 2007)
  • player in Slit-Robo signaling in cancer cell migration and required for Slit responsiveness in breast cancer cells (Yuasa-Kawada 2009)
  • required for Slit-induced Robo1 relocation to the plasma membrane (Yuasa-Kawada 2009)
  • role in vertebrate commissural axon guidance and in SLIT1 signaling (Yuasa-Kawada 2009)
  • required for SLIT1 responsiveness of commissural neurons (Yuasa-Kawada 2009)
  • USP33 and USP20 coordinate ADRB2 recycling and resensitization
  • is a deubiquitinase that has been associated with a variety of physiological events
  • USP33 potently and specifically deubiquitinates CCP110, but not other cyclin-F substrates
  • is a previously unknown tumor-suppressing gene for colorectal cancer (CRC) by mediating the inhibitory function of Slit-Robo signaling on CRC cell migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VHL (target for ubiquitination and degradation by pVHL E3 ligase)
  • interacting with SELENBP1 (Jeong 2009)
  • interacts with ROBO1 and is required for Slit-induced ROBO1 redistribution to the plasma membrane without affecting the total ROBO1 protein level (Yuasa-Kawada 2009)
  • USP33 interacts with CCP110 and localizes to centrioles primarily in S and G2/M phases, the periods during which centrioles duplicate and elongate
  • HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33
  • ubiquitination by the E3 ligase NEDD4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated ADRB2
  • BTRC interacted with USP33 independently of the classic binding motif for BTRC, and mediated USP33 degradation via the ubiquitin proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in multiple cohorts of lung cancer patients and low expression of USP33 is associated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • independent prognostic biomarker for papillary thyroid carcinoma (PTC), low USP33 expression indicated high recurrence risk
  • potential value of USP33 as an independent prognostic marker of colorectal cancer (CRC)
  • Therapy target
    ANIMAL & CELL MODELS