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FLASH GENE
Symbol NLGN1 contributors: mct/pgu - updated : 11-12-2009
HGNC name neuroligin 1
HGNC id 14291
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal specific interaction with the GOPC PDZ domain
  • extracellular domain sufficient to induce assembly of functional presynaptic terminals, while the intracellular domain was required for terminal maturation
  • HOMOLOGY
    interspecies homolog to rattus neuroligin 1
    Homologene
    FAMILY
  • neuroligin (Nlgn) family of postsynaptic transmembrane proteins
  • type-B carboxylesterase/lipase family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text post synaptic
    basic FUNCTION
  • mediating cell to cell interactions between neurons
  • triggering presynaptic development in contacting axon
  • induces apparent synapse formation by binding to presynaptic alpha-neurexins
  • essential role for presynaptic terminal maturation
  • also involved in critically controls key steps of presynaptic bouton maturation
  • performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities
  • with CDH2, cooperate to control vesicle clustering at nascent synapses
  • postsynaptic adhesion protein that control the maturation and function of synapses in the central nervous system (CNS)
  • NLGN1 and NLGN2 are essential for excitatory and inhibitory synaptic functions
  • postsynaptic cell-adhesion protein specific for excitatory synapses, which shares a high degree of similarity with acetylcholinesterase
  • acts as a nucleating factor during the APP aggregation process, stimulating the formation of APP oligomers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text formation and remodeling of central nervous system synapses
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta neurexins
  • interacting with GOPC (GOPC interacts with many other proteins, such as the Wnt receptors Frizzled 8 and neuroligin via its PDZ domain)
  • cooperation of CDH2 and NLGN1 via the postsynaptic scaffolding web is required to transsynaptically induce presynaptic vesicle clustering
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS