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FLASH GENE
Symbol DOCK9 contributors: mct - updated : 09-03-2011
HGNC name dedicator of cytokinesis 9
HGNC id 14132
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal CZH1 domain, conserved among CZH proteins, and the Pleckstrin homology domain are involved in membrane localization, CDC42 activation, and regulation of dendrite growth
  • a DHR-2 (CZH-2) domain
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus TRG protein
    intraspecies paralog to DOCK11 (52p100))
    Homologene
    FAMILY
  • superfamily of guanine nucleotide exchange factors for Rho GTPases
  • Dock180-related family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • CDC42 guanine nucleotide exchange factor, having potential guanyl-nucleotide release factor activity
  • implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution
  • specific guanine-nucleotide exchange factor (GEF) for CDC42
  • plays an important role in dendrite growth in hippocampal neurons through activation of CDC42
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component dimerizes via the CDC42-binding CZH2 domain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CDC42 via the CZH2 doamin
  • interacting with Rac2 and Cdc42 (specifically recognize Rac2 and Cdc42 through its switch 1 as well as 2-3 regions)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promoted dendrite growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS