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FLASH GENE
Symbol CDC14A contributors: mct - updated : 01-07-2016
HGNC name CDC14 cell division cycle 14 homolog A (S. cerevisiae)
HGNC id 1718
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae Cdc 14
intraspecies homolog to PTEN
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus,nucleoplasm
text
  • dynamically localizes to interphase but not mitotic centrosomes
  • located at the centrosomes during interphase
  • basic FUNCTION
  • dual specificity serine/threonine-tyrosine phosphatase, involved in cell cycle function and in tumorigenesis
  • involved in the exit of cell mitosis and initiation of DNA replication
  • its upregulation prevents targeting of exocyst and SNARE complexes to the midbody, both essential for abscission to occur 5)
  • CDC14A phosphatase prevents premature activation of CDK1 regulating CDC25A and CDC25B at the entry into mitosis 3)
  • down-regulates CDC25 activity at the G2/M transition to prevent premature activation of CDK1-Cyclin B1 complexes and untimely entry into mitosis
  • CDC14A phosphatase plays a role in cell cycle control in higher eukaryotes
  • play a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in cells
  • counteracts CDK1-cyclin B1 activity through WEE1 dephosphorylation
  • redundancy between CDC14B and CDC14A in DNA Double-Strand Break Repair repair
  • role for CDC14A in cell migration and adhesion that is clearly distinct from the mitotic and cytokinesis functions of Cdc14/Flp1 in budding and fission yeast
  • is the second DFNB gene reported to be involved in the control of kinocilium growth
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53
  • impacts the emerging signaling pathway between MAPK4 and MK5, a MAPK-activated protein kinase
  • CDC14A plays an important role in the regulation of WEE1 stability
  • CDC14A counteracts CDK1-CCNB1 activity through WEE1 dephosphorylation
  • DAPK3 may be involved in the regulation of the cell cycle in human cells, by interacting with CDC14A
  • cell & other
    REGULATION
    Other regulated by BRAP (facilitates CDC14A Lys-63 linked ubiquitin modification) (Chen 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB105
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS