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FLASH GENE
Symbol RNF14 contributors: mct/npt - updated : 02-07-2008
HGNC name ring finger protein 14
HGNC id 10058
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING (C3HC4-type) zinc finger motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • RING finger protein family
  • CATEGORY transcription factor , signaling hormone
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • coactivator of AR mediated transactivation in prostate, effect inhibited by a RNF14 (ARA54) dominant negative mutation
  • androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation
  • playing a role in the regulation of cyclin D1 expression in the absence of AR stimulation in cancer cells
  • might participate in enhancing cell cycle progression and cell proliferation via induction of cyclin D1 (CCND1)(Kikuchi 2007)
  • androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation (Kikuchi 2007)
  • may play an important role in testicular development and spermatogenesis in humans (Lan 2008)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased expression is a feature of nonobstructive azoospermia (Lan 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS