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FLASH GENE
Symbol TLR6 contributors: mct/npt - updated : 11-02-2013
HGNC name toll-like receptor 6
HGNC id 16711
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 20 tandemly repeated extracellular leucine-rich motifs(LRR)
  • a cysteine-rich region
  • a transmembrane segment
  • a cytoplasmic domain
  • the Toll homology domain common to the Toll and IL1 receptor genes (also called TIR domain)
  • HOMOLOGY
    interspecies homolog to Drosophila transmembrane receptor Toll,6
    Homologene
    FAMILY
  • Toll-like receptor family
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • transmembrane protein type I
  • TLR1, TLR2, TLR6, and TLR10 are displayed on the plasma membrane where they are best available to contact bacterial and fungal cell wall constituents
  • basic FUNCTION
  • recruited to macrophage phagosome in association to TLR2 where they recognize peptidoglycan, a Gram+ pathogen component (pathogen recognition and activation of innate immunity)
  • play a major role in initiating innate immune responses against microbes (Barreiro 2009)
  • expression of TLR6 may be a key factor in determining whether the first trimester trophoblast response to peptidoglycan would be apoptosis or inflammation (Abrahams 2008)
  • TLR1, TLR2, TLR6, and TLR10, mediates immune responses to a variety of microbial cell wall components including lipoproteins and glycolipids
  • TLR1, TLR2 and TLR6 were expressed on the surface of B cells, monocytes and dendritic cells in a manner dependent on TLR-specific chaperone CNPY3
  • lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text apoptosis of infected cells
    PATHWAY
    metabolism
    signaling signal transduction
    NF-kappa B and JNK pathways
    a component
  • heterodimerizes with TLR1 or TLR2 (Kang 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TLR2
  • activating NF-kappaBs signaling pathway
  • inducing TNF and IL6 production
  • interacting with IL10 (TLR6 is a distinct receptor driving regulatory IL10 response) (Depaolo (2008)
  • cell & other
    REGULATION
    induced by hypoxia (coordinated induction of TLR2 and TLR6 during hypoxia suggesting tissue hypoxia in transcriptional adaptation of innate immune responses during acute infection or inflammation) (Kuhlicke 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS