basic FUNCTION
| recruited to macrophage phagosome in association to TLR2 where they recognize peptidoglycan, a Gram+ pathogen component (pathogen recognition and activation of innate immunity) |
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play a major role in initiating innate immune responses against microbes (Barreiro 2009) |
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expression of TLR6 may be a key factor in determining whether the first trimester trophoblast response to peptidoglycan would be apoptosis or inflammation (Abrahams 2008) |
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TLR1, TLR2, TLR6, and TLR10, mediates immune responses to a variety of microbial cell wall components including lipoproteins and glycolipids |
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TLR1, TLR2 and TLR6 were expressed on the surface of B cells, monocytes and dendritic cells in a manner dependent on TLR-specific chaperone CNPY3 |
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lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface |