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FLASH GENE
Symbol ARFGEF1 contributors: mct - updated : 10-04-2014
HGNC name ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
HGNC id 15772
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SEC7 domain characteristic of ARF gamma nucleotide exchange proteins
  • C-terminal region including a binding site for myosin IXb
  • HOMOLOGY
    Homologene
    FAMILY Sec7 family of ADP-ribosylation factor (ARF) guanine nucleotide-exchange proteins (GEP)
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope
    text
  • cytosolic and colocalizing with COPB1 in a perinuclear structure probably with Golgi membranes
  • GBF1 acts at the cis-Golgi, whereas ARFGEF1 and its close paralog ARFGEF2 act at the trans-Golgi
  • basic FUNCTION
  • activators of ADP-ribosylation factor GTPases that are essential for regulating vesicular traffic among intracellular organelles
  • preferentially activates ADP-ribosylation factor 1 (ARF1) and ARF3
  • also involved in nuclear functions
  • required for correct glycosylation and function of integrin beta1 and playing a role in cytoskeletal dynamics through integrin-beta1-mediated signaling
  • ARFGEF1, ARFGEF2 play redundant roles in trafficking between the TGN and endosomes that involves the AP-1 complex
  • ARFGEF1 is required to maintain the normal morphology of the Golgi but ARFGEF2 is important for endosomal compartment integrity and cannot replace the function of ARFGEF1 in Golgi organization
  • effects of ARFGEF1 and KANK1 proteins on cell polarity and directed migration during wound healing
  • Arf guanine nucleotide-exchange factors ARFGEF1, ARFGEF2 and regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component with ARFGEF2 of a macromolecular complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARF proteins
  • binding partner for myosin IXb, which inhibited the GAP activity of myosin IXb (MYO9B)
  • interacting with KIF21A
  • ARL1 is necessary for Golgi recruitment of ARFGEF1 and ARFGEF2 but not GBF1
  • through its ability to activate ADP-ribosylation factor 1, regulates cell-surface levels and function of ABCA1, indicating a transcription-independent mechanism for controlling ABCA1 action
  • GBF1-activated ARFs (ARF4 and ARF5, but not ARF3) facilitate ARFGEF1 and ARFGEF2 recruitment to the trans-Golgi network (TGN)
  • cell & other
    REGULATION
    inhibited by brefeldin A
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS