SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| text
| colocalizing with COPB1 in a perinuclear structure probably with Golgi membranes |
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GBF1 acts at the cis-Golgi, whereas ARFGEF1 and its close paralog ARFGEF2 act at the trans-Golgi  |
| basic FUNCTION
| playing an important role in vesicular and membrane trafficking from the trans-golgi network |
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involved in the activation of ARFs (ARF1, ARF5 and ARF6) by accelerating replacement of bound GDP with GTP |
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activator of ADP-ribosylation factor GTPases that are essential for regulating vesicular traffic among intracellular organelles |
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ARFGEF1, ARFGEF2 play redundant roles in trafficking between the TGN and endosomes that involves the AP-1 complex |
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ARFGEF1 is required to maintain the normal morphology of the Golgi but ARFGEF2 is important for endosomal compartment integrity and cannot replace the function of ARFGEF1 in Golgi organization |
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alone or in concert with recruited MYCBP coordinates ARF-mediated membrane trafficking and signaling pathways |
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may coordinate actin cytoskeleton mechanics and membrane traffic in cell migration via ITGB1 action and actin functions |
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involved in the activation of ARFs by accelerating replacement of bound guanosine diphosphate (GDP) with Guanosine triphosphate (GTP), and is involved in Golgi transport |
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Arf guanine nucleotide-exchange factors ARFGEF1, ARFGEF2 and regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex |
