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Symbol EHD1 contributors: mct/npt/pgu - updated : 09-12-2015
HGNC name EH-domain containing 1
HGNC id 3242
  • an N-terminal ATPase domain
  • a highly conserved ATP/GTP binding domain
  • a central coiled-coil structure
  • a EPS15 (EH) domain including an EF hand-Ca2 binding motif at the C terminus, involved in targeting EPS15 into clathrin-coated pits,
  • a C-terminal nucleotide-binding motif
  • a central coiled-coil involved in oligomerization
  • C-terminal EH domain binding to proteins containing either an Asn-Pro-Phe or Asp-Pro-Phe motif, and playing an important role in the subcellular localization and function
  • conjugated PhosphoP
    interspecies homolog to murine Dres134 (expressed in embryonic CNS,PNS,retina and gut,testilin)
    homolog to Drosophila past testilin
    ortholog to murine Ehd1
    intraspecies paralog to EHD3, EHD2, EHD4
  • EPS15 homology (EH) domain family
  • C-terminal Eps15 homology domain (EH) containing protein family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
  • EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket
  • basic FUNCTION
  • potentially participating as a down-regulator, in clathrin-coated pit-mediated endocytosis of IGF1 receptor after binding to its ligand
  • implicated in the recycling of internalized proteins to the plasma membrane
  • ZFYVE20 and EHD1 may act sequentially in the transport of proteins from early endosomes to the endosomal recycling compartment and back to the plasma membrane
  • regulate the exit of cargo from the recycling endosome
  • colocalize with vesicular and tubular structures, implying roles in transport processes and cytoskeletal dynamics and interact with specific phospholipids
  • also potentially involved in signal transduction pathways, downstream of receptor tyrosine kinases
  • functions in the recycling of membrane proteins from recycling endosomes to plasma membrane
  • play a critical role in the recycling of plasma membrane receptors (i.e., transferrin) that are internalized either through clathrin-coated pits or independently of clathrin
  • may impact the storage of esterified cholesterol in the organelles (lipid droplets)
  • phosphorylation occuring between early endosomes and endocytic recycling compartment
  • may be playing a role in the endocytosis of IGF1 receptors
  • plays an important role in regulating beta1 integrin transport, and required in integrin-mediated downstream functions
  • key regulator of endocytosis and associates with tubular membranes to facilitate recycling
  • affects the coupling of synaptotagmin-1 to the SNARE complex, and could be a negative regulator of exocytosis
  • synaptic protein that negatively affects exocytosis through binding to SNAPIN
  • regulates the trafficking of multiple receptors from the endocytic recycling compartment (ERC) to the plasma membrane
  • role for EHD1 in regulating the trafficking of CD59, an endogenous GPI-AP, at early stages of trafficking through the endocytic pathway
  • functions in the recycling endosome and is required for endosome-to-plasma membrane transport of multiple cargos
  • in neurons, EHD1 functions in early endosomes rather than (or possibly in addition to) recycling endosomes
  • EHD proteins and ferlin proteins form discrete structures in myoblasts
  • enriched at synaptic release sites, suggesting a possible involvement in the trafficking of synaptic vesicles
  • PLA2G4A and EHD1 are involved in the vesiculation of CD59-containing endosomes
  • the functions of both EHD1 and EHD4 are primarily in tubular recycling endosomes (TREs) membrane vesiculation, whereas EHD3 is a membrane-tubulating protein
  • EHD1 and EHD3 reorganize the M-centriole and associated distal appendage vesicles (DAVs) before coordinated ciliary membrane and axoneme growth
  • EHD1 and EHD3 control traffic to the endocytic recycling compartment (ERC) and from the ERC to the plasma membrane, while EHD2 modulates internalization
    a component
    small molecule metal binding, nucleotide,
  • ATP/GTP binding
  • ions Ca2+ binding
  • protein
  • interacting with SNAP29 and associating with the AP2 adaptor protein complex to initiate endocytic vesicle formation
  • interacting with EHD3
  • interacting with IGF1-R
  • interaction with Rab11 effector protein, Rab11-FIP2, suggesting that EHD1 regulates the transport of Rab11-FIP2-and Rab11-containing vesicles
  • interacts with a synaptic protein, snapin
  • FER1L5 binds directly to the endocytic recycling proteins EHD1 and EHD2 and the second C2 domain in FER1L5 mediates this interaction
  • ANKFY1 is an interaction partner for the recycling regulatory protein EHD1
  • ARF35 regulates the formation of an EHD1-association site on ARF6-positive endosomes by integrating the functions of two distinct RAB35 effectors for successful neurite outgrowth
  • cell & other
    Other ATP-binding is required for oligomerization