basic FUNCTION
| lymphocyte chemoattractant (chemotractive for eosinophils and basophils) |
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acting as a CCR3 ligand |
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inhibiting CCL2 -mediated responses, thus acting as a natural antagonist for CCR2 and exerting a repulsive effect on monocytes |
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first chemokine that features broadband antagonistic activities, suggesting that it may have a modulatory rather than an inflammatory function |
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CCL26 may be partly responsible for the recruitment of cells expressing CX3CR1 in atopic dermatitis particularly when the expression of CX3CL1 is low |
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CCL26, CCL24, CCL11 have the ability to regulate extravillous trophoblast (EVT) functions critical to their role in vessel remodelling, suggesting a new role for the eotaxin group of chemokines during placentation |
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CCL11, CCL24, and CCL26 are chemokines involved in the recruitment of eosinophils into tissues and that mainly activate CCR3 |
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CCL26 may play a unique and important role in the recruitment of eosinophils in persistent asthma |
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CCL11, CCL24, and CCL26 all showed potent bactericidal activity, mediated through membrane disruption, against the airway pathogens Streptococcus pneumoniae, Staphylococcus aureus, Nontypeable Haemophilus influenzae, and Pseudomonas aeruginosa |
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eotaxins can contribute to host defense against common airway pathogens and that their activities are modulated by mast cell proteases |
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CCL26 participates likely in the movement of eosinophils from the tissues to the airway lumen |
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role for CCL26 in the sustained inflammation observed in patients with severe eosinophilic asthma |