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FLASH GENE
Symbol CCL26 contributors: mct - updated : 05-12-2008
HGNC name chemokine (C-C motif) ligand 26
HGNC id 10625
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
a 23 amino acid signal peptide
secondary structure an unstructured N terminus before the first two conserved Cys, an irregularly structured N-loop following the second conserved cys, a single turn of 3(10)-helix, a three stranded antiparallel beta-sheet, an alpha-helix and an unstructured C terminal tail
mono polymer monomer
HOMOLOGY
interspecies homolog to C.elegans y116f11b.1
homolog to Drosophila eg:bacr25b3.3
Homologene
FAMILY intercrine beta family
CATEGORY immunity/defense , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • lymphocyte chemoattractant (chemotractive for eosinophils and basophils)
  • acting as a CCR3 ligand
  • inhibiting CCL2 -mediated responses, thus acting as a natural antagonist for CCR2 and exerting a repulsive effect on monocytes
  • first chemokine that features broadband antagonistic activities, suggesting that it may have a modulatory rather than an inflammatory function
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS inflammation
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling signal transduction
    cell to cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to receptor CCR3
  • antagonizing CCR1, CCR2, CCR5
  • CREB1 gene silencing decreased IL13-induced transcription of eotaxin-3 (CCL26)
  • cell & other
    REGULATION
    induced by IL13 and IL14 in HUVECand IL4
    Other regulated by STAT6 (in dermal fibroblasts)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma and total IgE dosage
    Variant & Polymorphism SNP 77C > T, +716A > G, EOT 3 +1579G > A increasing the risk of asthma
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergy  
    CCR3 and CCR5 receptor/ligand signaling pathways may be important targets for development of novel mechanism-based adjunctive therapies designed to abrogate the chronic inflammation associated with airway diseases
    ANIMAL & CELL MODELS