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FLASH GENE
Symbol MASP2 contributors: mlc - updated : 18-10-2007
HGNC name mannan-binding lectin serine protease 2
HGNC id 6902
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short consensus repeats, sushi structure
  • N-terminal CUB domain, and the EGF-like domain
  • C-terminal sequence (EQSL) and lacks the serine protease catalytic domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION serine protease involved in the mannan-binding lectin pathway of complement activation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forms Ca(2+)-dependent complexes with mannan-binding lectin (MBL) and L-ficolin
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MASP2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer, significantly correlated with recurrent cancer disease and with poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS