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FLASH GENE
Symbol PHF2 contributors: mct - updated : 10-10-2017
HGNC name PHD finger protein 2
HGNC id 8920
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PHD (C4-H-C3) zinc finger domain
  • eight nuclear localization signals (NLS)
  • two PEST and a hydrophobic domain
  • HOMOLOGY
    interspecies homolog to Drosophila polycomb group PcG
    Homologene
    FAMILY
  • JHDM1 histone demethylase family
  • JHDM1D subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator affecting gene expression by influencing chromatin structure
  • co-activator function having important functional roles in neuronal development
  • PHF2, PHF8, possess a PHD domain-dependent di-/trimethylated histone 3 lysine 4 (H3K4me2/3) binding activity and are known to be enriched in the nucleolus
  • repressive role for PHF2 in transcription by RNA polymerase I and II
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PHF2-ARID5B complex is a signal-sensing modulator of histone methylation and gene transcription, in which phosphorylation of PHF2 enables subsequent formation of a competent and specific histone demethylase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylated PHF2 then associates with ARID5B, a DNA-binding protein, and induce demethylation of methylated ARID5B
  • PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of rDNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS