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FLASH GENE
Symbol EMP3 contributors: - updated : 12-12-2006
HGNC name epithelial membrane protein 3
HGNC id 3335
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a carbohydrate linked chain with 2N-linked glycosylation sites in the extracellular domain
  • four membrane associated domains, homologous to the PMP22 protein
  • HOMOLOGY
    Homologene
    FAMILY PMP22/EMP/MP20 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in cell proliferation and cell-cell interactions
  • myelin-related gene epigenetically silenced and exhibiting features of a candidate tumor suppressor in glioma and neuroblastoma
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in neuroblastoma associated with poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS