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FLASH GENE
Symbol ABCB10 contributors: mct/npt - updated : 21-03-2019
HGNC name ATP-binding cassette, sub-family B (MDR/TAP), member 10
HGNC id 41
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal unusually long 105-amino acid mitochondrial targeting presequence (mTP)
  • two ATP binding and two transmembrane domains (2x6 segments)
  • mono polymer homomer , dimer , oligo
    HOMOLOGY
    interspecies homolog to E.coli INFA
    Homologene
    FAMILY
  • ABC transporter superfamily
  • ABCB family
  • mitochondrial peptide exporter subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • mitochondrial inner membrane erythroid transporter involved in heme biosynthesis
  • may be having a physiological role in the antigen processing
  • mitochondrial inner membrane ATP-binding cassette transporter highly induced during erythroid maturation in hematopoietic tissues (Chen 2009)
  • half-transporter functioning as a homodimer and required for SLC25A37 protein stability and mitochondrial iron import in erythroid cells (Chen 2009)
  • critical role for ABCB10 in heme biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FECH forms an oligomeric complex with SLC25A37 and ABCB10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis
  • a dimeric FECH physically bridged ABCB7 and ABCB10 homodimers by binding near the NBDs of each ABC transporter
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with SLC25A37 to enhance its protein stability and, as a consequence, increase iron import into the mitochondria (Chen 2009)
  • SLC25A37 interacts with ABCB10 to enhance mitochondrial iron importation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS