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FLASH GENE
Symbol SEC22B contributors: mct/npt - updated : 05-12-2018
HGNC name SEC22 vesicle trafficking protein homolog B (S. cerevisiae)
HGNC id 10700
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • synaptobrevin domain
  • signal peptide and transmembrane region
  • a R-SNARE motif, a selective domain for forming a SNARE complex with STX18 and/or USE1, was responsible for the inhibition of phagocytosis (Hatsuzawa 2009)
  • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Sec22-like 1
    Homologene
    FAMILY
  • synaptobrevin family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text ER-localized SNARE protein which is also found on phagosomal membranes (Hatsuzawa 2009)
    basic FUNCTION
  • involved in vesicular trafficking between ER and the Golgi apparatus
  • ER-localized SNARE protein, negative regulator of phagocytosis in macrophages, most likely by regulating the level of free STX18 and/or USE1 at the site of phagocytosis (Hatsuzawa 2009)
  • MIA2 may coordinate with SEC22B to control the release of COPII vesicles from the ER, and thereby the ER-to-Golgi trafficking of proinsulin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component ER (endoplasmic reticulum)-localized syntaxin 18 (Qa-SNARE) forms a complex with BNIP1 (Qb-SNARE), USE1(Qc-SNARE), SEC22B (R-SNARE) and several peripheral membrane proteins (Aoki 2008)
    INTERACTION
    DNA
    RNA
    small molecule
    protein association with SEC22B induces an increase in alpha-helicity of their SNARE motifs, which results in the formation of high-affinity binding sites for BNIP1 and USE1 (Aoki 2008)
  • MIA2 interacts with vesicle membrane soluble N-ethyl-maleimide sensitive factor attachment protein receptor SEC22B and this interaction with MIA2 is essential for proinsulin processing
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS