motifs/domains
| an N-terminal TRAF binding domain and |
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a leucine zipper domains, |
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a conserved TRAF-C domain, required for self association (dimerization) and receptor binding, export sequences that cause shuttling between the cytoplasm and nucleus |
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a SXXE/D motifs found in the cytoplasmic domains of many TNFR family members and their adaptor proteins, that may serve to function as a specific interaction module for the alpha-helical death domain signal |
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a C terminal DEATH domain, comprising a coiled coil region, responsible for binding other DD-containing proteins including the p75 neurotrophin receptor (p75NTR) |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nucleus,nucleoplasm,nuclear bodies,PML
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text
| translocated to nucleus in the absence of export |
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TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between CDKN2A and its E3 ubiquitin ligase TRIP12, thereby promoting CDKN2A stability and tumour suppression |
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cytoplasmic TRADD translocates to DNA double-strand break sites (DSBs) during the DNA damage response (DDR) |
basic FUNCTION
| recruiting signaling molecules to the TNFRSF1A (TNFR1) complex |
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mediating programmed cell death apoptosis and activating NF-Kappa B distinctly |
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activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm (can regulate cell death independently of FADD and caspase-8 that occurs from the nucleus rather than the cytoplasm) |
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may be a critical player in the host antiviral and antibacterial response |
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plays an important role in TLR signaling via participation in TICAM1-dependent NFKB activation |
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biological function of TRADD in TNF signaling ( |
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plays a survival role in TNFSF10 signaling |
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key effector protein of TNFR1 signaling |
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essential role of TRADD in DR3 (death receptor) signaling |
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has a survival role in TNFSF10 signaling and may be one potential target for overcoming TNFSF10 resistance in cancer therapy |
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oncogenic role for TRADD in glioblastoma multiforme (GBM) |
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FADD and TRADD proteins are important regulators of cell fate in mammalian cells |
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translocation of TRADD to DSBs into the nucleus contributes to cell survival in response to DNA damage through an activation of DNA damage repair |
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is an intracellular adaptor protein involved in various signaling pathways, such as antiapoptosis |