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FLASH GENE
Symbol PARP3 contributors: mct - updated : 28-06-2011
HGNC name poly (ADP-ribose) polymerase family, member 3
HGNC id 273
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the N-terminal domain composed of 54 amino acids is responsible for its centrosomal localization
  • the catalytic domain in the C-terminal region
  • conjugated RiboP , Other
    HOMOLOGY
    interspecies ortholog to murine Adprtl3
    intraspecies homolog to ADPRT
    Homologene
    FAMILY ARTD(PARP) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • core component of the centrosome
  • preferentially localized to the daughter centriole throughout the cell cycle
  • basic FUNCTION
  • ADP-ribosyltransferase (NAD+,poly ADPribose polymerase)-like 3
  • involved in the base excision repair (BER) pathway, by catalysing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism
  • may link the DNA damage surveillance network to the mitotic fidelity checkpoint
  • negatively influences the G1/S cell cycle progression without interfering with centrosome duplication
  • involved in detection/signaling pathway leading to the reparation of DNA strand breaks
  • nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage
  • molecular roles for PARP3 and APLF in chromosomal DNA double-strand break repair reactions (
  • catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory
  • particular role of PARP3 in cellular response to double-strand breaks, most likely in concert with PARP1
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component auto-poly(ADP)-ribosylation
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interaction between PARP1 and PARP3 is unrelated to DNA single-strand break repair
  • interacting with APLF (molecular roles for PARP3 and APLF in chromosomal DNA double-strand break repair reactions)
  • cell & other
    REGULATION
    activated by DNA double-strand breaks (DSBs) and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate chromosomal DNA DSB repair
    induced by DNA breaks
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS