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FLASH GENE
Symbol NCR1 contributors: mct - updated : 09-03-2012
HGNC name natural cytotoxicity triggering receptor 1
HGNC id 6731
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two C2-type Ig-like extracellular domains, assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs)
  • a transmembrane domain associating with CD3Z
  • a cytoplasmic tail without the immunoreceptor tyrosine based activation motif (ITAM)
  • HOMOLOGY
    interspecies homolog to murine Ly94
    homolog to Drosophila cg7565
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • major activating receptor involved in the recognition and lysis of tumor cells
  • having a role in NK cell activation
  • involved in NK cell activation mediated by non-HLA class I ligands
  • critical and differential roles of NCR1- and NCR3-activating receptors expressed by uterine NK cells in early pregnancy
  • NCR1, NCR2, NCR3 are thought to be NK lineage restricted
  • with NCR2 and NCR3, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands
  • essential for the development of type 1 diabetes and is a potential new therapeutic modalities for this disease
  • specific NK killer receptor that recognizes various influenza hemagglutinins and unknown tumor ligands
  • major killer receptor expressed by NK cells, recognizing an unknown ligand expressed by pancreatic beta cells and in the absence of NCR1, or when its activity is blocked, diabetes development is inhibited
  • cell surface receptor expressed on natural killer (NK) cells, on a minute subset of T cells, and on a population of innate lymphoid cells that produce IL22
  • critical for the subsequent development of antiviral and antibacterial T cell responses, suggesting that the regulation of NK cell function by NCR1 allows for the optimal development of adaptive immune responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular defense response/killer activity
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could represent an additional marker on the circulating malignant T lymphocytes of Sézary patients
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 1 
    new therapeutic target for type 1 diabetes
    ANIMAL & CELL MODELS
  • NKp46-deficient mice had less development of type 1 diabetes induced by injection of a low dose of streptozotocin