basic FUNCTION
| splicing factor, modulating the affinity between RS domain containing proteins and regulating the cellular distribution of their substrates |
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playing a role in the spliceosome assembly |
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may play an important role in linking signaling to RNA metabolism in higher eukaryotic cells |
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controling localization of splicing factors |
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implicated in spliceosome assembly and catalytic activation |
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playing a role in splicing |
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protein kinase specific for the serine/arginine (SR) family of splicing factors, triggering cell cycle progression in neurons and inducing apoptosis through regulation of nuclear cyclin D1 |
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its phosphorylation is necessary for phosphatidylinositol 3-kinase/Akt mediating the cell cycle and cell death machinery in the nervous system |
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phosphorylate serine/arginine (SR) domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing |
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involved in the molecular chaperone system that has been implicated in numerous signal transduction pathways and provide mechanistic insights into complex regulation of SR protein phosphorylation and alternative splicing in response to developmental cues and cellular signaling |
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phosphorylate SR domain-containing proteins in the nuclear speckles and mediate the pre-mRNA splicing |
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in addition to phosphorylating SR proteins and regulating pre-mRNA splicing, SRPK1 and SRPK2 also play an important role in cell proliferation and apoptosis |
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active SRPK2 can trigger apoptosis which depends on its kinase activity and is also a substrate of caspases whose action releases an N-terminal fragment from the kinase, involved in apoptotic cell death |