| basic FUNCTION
| steroid hormone receptor |
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transcriptional repressor |
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orphan nuclear receptors that function as dominant transcriptional silencer |
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potent transcriptional repressor that regulates circadian rhythm and metabolism |
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being necessary for the early mitotic events that are required for adipogenesis |
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participates in the circadian modulation of sterol regulatory element-binding protein (SREBF) activity, and thereby in the daily expression of SREBF target genes involved in cholesterol and lipid metabolism  |
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repression of gene transcription by NR1D1 plays an integral role in the core molecular circadian clock |
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RORA and NR1D1 coordinately regulate the expression of the positive arm of the circadian rhythm feedback loop |
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transcriptional repressor that is expressed in a circadian manner and the abundance of NR1D1 protein oscillated in phase with HDAC3 recruitment |
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colocalizes with HDAC3 near genes regulating lipid metabolism |
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genomic recruitment of HDAC3 by NR1D1 directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis |
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a potential role for NR1D1, in conjunction with its cofactor NR2E3, in regulating transcriptional networks critical for photoreceptor development and function ( |
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plays a dual role in regulation of the activity of the ARNTL/CLOCK heterodimer by regulation of expression of both the ARNTLand CLOCK genes |
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mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines |
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NR1D1, NR1D2 are major regulators of both clock function and metabolism, displaying a level of subtype collaboration that is unusual among nuclear receptors but common among core clock proteins |
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controls circadian oscillations of several clock genes and its degradation is important for maintenance of the circadian oscillations and also for adipocyte differentiation |
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is a pharmacological target that improves muscle oxidative function by modulating gene networks controlling mitochondrial number and function |
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may be a key link between aging- or obesity-associated impairment of clockwork and inflammation |
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NR1D1 and NR4A1 serve similar or complementary functions in the APOA4-mediated regulation of gluconeogenesis |
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NR1D1 and NR1D2 are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes |
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plays a major role in retinal information processing |
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nuclear receptor that is part of the circadian clock mechanism and regulates metabolism and inflammatory processes |
