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FLASH GENE
Symbol HDC contributors: mlc - updated : 17-11-2007
HGNC name histidine decarboxylase
HGNC id 4855
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • pyridoxal phosphate (PLP)-dependent decarboxylase
  • catalyzing the histamine synthesis
  • catalyzes the conversion of histidine to histamine, a bioamine that plays an important role in allergic responses, inflammation, neurotransmission, and gastric acid secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling
    catecholamine
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    pyridoxal phosphate PLP
    protein
    cell & other
    REGULATION
    repressed by KLF4 (KLF4 can act to repress HDC gene expression by Sp1-dependent and -independent mechanisms)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS