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FLASH GENE
Symbol SESN1 contributors: mct/npt - updated : 26/09/2008
HGNC name sestrin 1
HGNC id 21595
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Pa26-pending
homolog to Drosophila CG11299
ortholog to xenopus Xpa26
Homologene
FAMILY
  • GADD family (growth arrest and DNA damage-inducible stress-response gene)
  • sestrin family
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having a role in the regulation of cell growth
  • required for normal embryonic left-right determination, playing a role in mediating Nodal signaling, and being indispensable gene for vertebrate left-right asymmetry
  • exhibit oxidoreductase activity and may function as antioxidants (Lee 2010)
  • important negative feedback regulator of MTOR whose loss results in various MTOR-dependent, age-related pathologie (Lee 2010)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative regulation of cell proliferation ; response to DNA damage
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53 target gene
  • physically interacts with FOXH1 or a FOXH1-containing complex
  • SESN1 and SESN2 interact with the NFE2L2 suppressor KEAP1, the autophagy substrate SQSTM1, and the ubiquitin ligase RBX1 and the antioxidant function of SESNs is mediated through activation of NFE2L2 in a manner reliant on SQSTM1-dependent autophagic degradation of KEAP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in a number of cancers and in heterotaxia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS