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FLASH GENE
Symbol BTF3 contributors: mct/npt - updated : 03/10/2008
HGNC name basic transcription factor 3
HGNC id 1125
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , complex
HOMOLOGY
interspecies homolog to murine Btf3
homolog to C.elegans C56C10.8
Homologene
FAMILY
  • NAC-beta family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for initiation of transcription from promoter elements such as TATA box
  • may be a component of the mechanism by which the AF-1 function of ESR1 stimulates gene transcription
  • acting as a transcription factor and modulator of apoptosis, and differentially expressed in colorectal cancer and glioblastomas
    • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a stable complex with RNA polymerase II
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forming a stable complex with RNA polymerase II
  • interacting with ESR1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS