Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC16A7 contributors: npt/ - updated : 10-09-2009
HGNC name solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
HGNC id 10928
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • sodium:neurotransmitter symporter (SNF) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text preferential postsynaptic localization of its synaptic expression (Chiry 2008)
    basic FUNCTION
  • high affinity pyruvate transporter
  • involved in the transport of lactate, pyruvate and ketone bodies (Chiry 2008)
  • having a putative role in adjustment of energy supply to levels of activity (Chiry 2008)
  • having a role in the transport of gamma-hydroxybutyric acid in mammalian cells (Wang 2007)
  • catalyse the proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate and ketone bodies (Halestrap 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
  • protein
  • CD147 (BSG)
  • interaction between EMB and SLC16A7 (ancillary protein EMB required to maintain the catalytic activity of SLC16A7 as well as for their translocation to the plasma membrane)(Wilson 2005)
  • cell & other
    REGULATION
    activated by estradiol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS