Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IL32 contributors: mct - updated : 13-05-2008
HGNC name interleukin 32
HGNC id 16830
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three potential N-myristoylation sites
  • one N-glycosylation site
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potentially involved in cell adhesion
  • may play a role in lymphocyte activation
  • inducing the production of TNFalpha from macrophage cells
  • playing a role in the pathophysiology of clonal myeloid diseases
  • not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells
  • may be playing a role in inflammatory bowel diseases
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in rheumatoid arthritis synovial tissue
    tumoral     --other  
    dysregulation in myelodysplastic syndrome (MDS) and myeloproliferative disorder
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target therapeutic targets for patients with myelodysplastic syndrome (MDS) and myeloproliferative disorder
    ANIMAL & CELL MODELS