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FLASH GENE
Symbol SLC7A8 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
HGNC id 11066
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4, the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • amino acid-polyamine-organocation (APC) superfamily
  • L-type amino acid transporter (LAT) family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • coexist with SLC16A10 in the basolateral membrane of the renal proximal tubules (Park 2005)
  • expressed in various tissues, including the intestinal wall, blood-brain barrier, and kidney (Del Amo 2008)
  • basic FUNCTION
  • involved in epithelial aminoacid (re)absorption, broad scope neutral aminoacids transporter
  • contribute to the renal reabsorption of neutral amino acids in the basolateral domain of epithelial proximal tubule cells (Park 2005)
  • play essential roles in the reabsorption of neutral amino acids from the epithelial cells to the blood stream in the kidney (Park 2005)
  • with SLC7A5, functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids (Omidi 2008)
  • may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism (Capelo 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein 4F2hc/CD98 at the basolateral membrane to form a complex mediating y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS