basic FUNCTION
| involved in eye development |
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recruited in the context of local chromatin to conduct transcriptional regulatory functions |
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inhibit c-Jun transactivation through recruitment of HDAC1 and HDAC3 to the domain of c-Jun |
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cell fate determination factor that inhibits cyclin D1 and breast tumor growth |
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inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8 |
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plays an important role in negative regulation of TNFSF11 gene expression in marrow stromal/preosteoblast cells in the bone microenvironment |
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important role in tumorigenesis, in particular, breast, prostate and ovarian cancer |
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selectively inhibited FOXM1-mediated contact-independent growth and occupancy in the context of local chromatin |
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competes as a DNA binding–specific transcription factor to attenuate signaling by the Forkhead family of transcription factors |
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distinctive tumor suppressor, which does not only suppress growth of tumor cells but also regulates FGF2-mediated tumor-initiating activity of glioma cells |
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its expression repressed growth of glioma cells |
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regulates retinal cell fate determination |
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role of DACH1 as a cell cycle regulator in myeloid cells |
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having a role as a tumor suppressor in breast cancer by regulating cell cycle progression and stem cell reprogramming factors |
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opposite roles of DACH1 associated with the regulation of the cell cycle machinery and expression of reprogramming factors in myeloid cells |
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is a novel coactivator of HOXA9 and has an oncogenic effect in hematopoietic malignancy |
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key signaling pathway for kidney development |
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zona glomerulosa selective gene in the human adrenal, activating TGFB1 signaling and suppressing aldosterone secretion |
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DACH1-mediated corepression in hepatocytes emerges as an important link between obesity and insulin resistance |
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chromosome-associated protein that regulates cellular differentiation throughout development |
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potential role for DACH1 in the development of human chronic glomerulopathy |