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FLASH GENE
Symbol ADGRG1 contributors: mct - updated : 21-09-2016
HGNC name adhesion G protein-coupled receptor G1
HGNC id 4512
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain with a large number of possible N- and O-linked glycosylation sites similar to mucin-like protein, extracellular domain containing a high percentage of serine and threonine residues, and capable of homophilic trans-trans interactions that enhance receptor signaling activity
  • extremely large N-terminal extracellular region (381 amino acids) with four cysteine residues that define a GPCR proteolytic site (GPS motif) just before the first transmembrane spanning domain
  • a long ectodomain (ECD)
  • a seven-pass transmembrane (7TM) moiety
  • HOMOLOGY
    interspecies homolog to rattus Gpr56 (79.62 pc)
    homolog to murine Gpr56 (79.33 pc)
    Homologene
    FAMILY
  • adhesion-GPCR family
  • LN-TM7 subfamily
  • secretin family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • abundantly localizes in the cerebral cortical ventricular and subventricular zones during periods of neurogenesis
  • present in abundance in radial glial endfeet
  • basic FUNCTION
  • having a role in the development of neural progenitor cells
  • required for proper development of the cerebral cortex
  • involved in neuropeptide signaling pathway and metabolism
  • involved in regulating cortical patterning, particularly in the frontal lobes, and in the normal development of the frontoparietal cortex
  • may function to control the proliferation of pluripotent cells of different origins
  • inhibits in cooperation with TGM2 melanoma tumor growth and metastasis
  • functioning as an adhesion G-protein-coupled receptor and involved in adhesion signaling
  • participating in the regulation of neural progenitor cells movement through Rho signaling pathway, suggesting its important role in the development of the central nervous system
  • functions in regulating pial basement membrane (BM) integrity during cortical development
  • regulates the migration of neural precursor cells
  • adhesion G protein-coupled receptor that plays a key role in cortical development
  • plays an indispensable role in cortical development and lamination
  • roles of TGM2 in ADGRG1-mediated melanoma inhibition
  • is expressed during early stages of oligodendrocyte development and is a regulator of oligodendrocyte development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
  • coupling with Gs alpha protein and activating adenylate cyclase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds specifically to tissue transglutaminase, TG2, a widespread component of tissue and tumor stroma previously implicated as an inhibitor of tumor progression
  • associate via its N-terminal region with the extracellular matrix protein transglutaminase 2 and also shown to form complexes with the tetraspanins CD9 and CD81 via undetermined domains
  • COL3A1 is the ligand of GPR56
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • cell & other
    REGULATION
    Other could be activated to stimulate Rho signaling, thereby inducing actin cytoskeleton remodeling and the inhibition of cellular migration
    ASSOCIATED DISORDERS
    corresponding disease(s) BFPP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gliomas, in glioblastoma multiforme tumors and esophageal squamous cell carcinomas
    constitutional     --low  
    in neural progenitor cells
    tumoral        
    expression of GPR56 protein is suppressed in human pancreatic cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene can be used as an neural stem cell (NSC) or neural progenitor cell (NPC) marker within the neural cell lineage, especially in combination with nestin
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    components of the GPR56-mediated signaling pathway may serve as new targets for antiangiogenic treatment of melanoma
    ANIMAL & CELL MODELS
  • loss of the mouse Gpr56 gene leads to neuronal ectopia in the cerebral cortex, a cobblestone-like cortical malformation