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FLASH GENE
Symbol SLC24A1 contributors: mct - updated : 10-09-2009
HGNC name solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
HGNC id 10975
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two large hydrophilic loops
  • two sets of transmembrane spanning segments (TMs)
  • the first large hydrophilic loop is located extracellularly at the N-terminus
  • the other is cytoplasmic and separates the two sets of TMs
  • HOMOLOGY
    Homologene
    FAMILY
  • sodium/potassium/calcium exchanger family
  • SLC24A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • calcium extrusion protein,K dependent (Na+) (Ca2+) exchanger regulating intracellular Ca2+ concentration
  • polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors
  • probably play a particularly prominent role in regulating Ca2+ flux in environments which experience wide and frequent fluctuations in Na+ concentration
  • bidirectional transporters normally extruding Ca(2+) from the cell (forward exchange), but also able to carry Ca(2+) into the cell (reverse exchange) when the transmembrane Na(+) gradient is reversed
  • indispensible role of SLC24A1 in retinal function and/or maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSNB12
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS