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FLASH GENE
Symbol MOCS2 contributors: mct - updated : 04-05-2016
HGNC name molybdenum cofactor synthesis 2
HGNC id 7193
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved C-terminal double glycine motif, and extension of the C terminus with an additional glycine of MOCS2 and URM1 altered the localization of MOCS3 from the cytosol to the nucleus
  • first step of activation of both MOCS2 and URM1 consists of the formation of an acyl-adenylate group at the C-terminal glycine residue
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • moaE family
  • MOCS2B subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • dual localization in the cytoplasm and the nucleus
  • basic FUNCTION
  • bicistronic enzyme, catalyzing the second step of the molybdenum cofactor synthesis
  • converting precursor Z (see MOCS1) to molybdopterine
  • essential for the function of sulphite oxidase, xanthine dehydrogenase, and aldehyde oxidase enzymes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    molybdenum cofactor biosynthesis
    a component
  • heterodimer of a large and a small subunit
  • MOCS3 forms heterotetrameric complexes with both URM1 and MOCS2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both URM1 and MOCS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MOCODB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS