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Symbol KAT2B contributors: shn/npt/pgu - updated : 04-03-2016
HGNC name K(lysine) acetyltransferase 2B
HGNC id 8638
  • one acetyltransferase domain
  • one bromodomain
  • mono polymer heteromer , dimer
    interspecies homolog to GCN5, yeast
    ortholog to kat2b, Danio rerio
    ortholog to Kat2b, mus musculus
    ortholog to KAT2B, Pan troglodytes
  • GCN5 family
  • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • has histone acetyl transferase activity with core histones and nucleosome core particles
  • plays a direct role in transcriptional regulation
  • possessing intrinsic histone acetylase activity with core histones and nucleosome core particles
  • competing with an adenoviral oncoprotein E1A
  • inhibiting cell-cycle
  • acetylation of Myod
  • regulator with CREBBP of involucrin expression in stratified squamous epithelial cells
  • acting as a coactivator of ATF4 and is involved in the enhancement of DDIT3 transcription following amino acid starvation
  • playing a role in regulation of muscle contraction
  • probably takes part in transcriptional regulations of various BCR signalling- and apoptosis-related genes, especially including DFFA and BIRC2 genes
  • may control transcription both positively and negatively at the level of chromatin modification and via direct interactions with the TATA-binding protein (TBP)
  • might be the target tumor suppressive gene responsible for the 3p24 deletion event in esophageal squamous cell carcinoma
  • inhibits the activity of cyclin/CDK2 complexes
  • acts downstream of PTH signaling as a transcriptional coactivator that is required for PTH stimulation of MMP13 transcription
  • required for stress-responsive histone 3 acetylation at the CDKN1A promoter, TP53-directed transcription of CDKN1A and the resultant growth arrest
  • functions as a transcriptional coactivator, which may facilitate the formation of memory for fear extinction by interfering with reconsolidation of the original memory trace
  • function in mitotic chromosome congression by regulating spindle plus-end dynamics
  • important regulator for promoting osteoblast differentiation via acetylation modification of RUNX2
  • CELLULAR PROCESS cell cycle, progression
    cell life, differentiation
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
  • muscle differentiation
  • calcium-induced keratinocyte differentiation
    signaling hormonal
    a component
  • component of the mammalian STAGA (SUPT3H-TAF9-ADA-PCAF acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors
  • with BCR signalling are essential for apoptotic cell death
  • part of a GCN5/PCAF Complex (ATAC) distinct from STAGA
  • both STAGA and ATAC acetylate specifically nucleosomal histone H3
    small molecule
  • acetylating SCL (TAL1)
  • CBP and p300
  • activating HDAC13
  • binding to TP73(coactivator for TP73-mediated transactivation
  • MYOD1
  • interaction partner of ATF4 in leucine-starved cells
  • PTEN
  • directly interacts with CDK2 (this interaction is mainly produced during S and G(2)/M phases of the cell cycle)
  • KLF8 activation domain located between AAs 101-260 where the well-conserved Q118 and Q248 are essential for recruiting EP300 and KAT2B to activate target gene transcription
  • ESRRA interacts with and is acetylated by EP300 coactivator associated factor (KAT2B)
  • cooperates with EP300 and RUNX2 to mediate PTH activation of MMP13 transcription
  • induces CDKN1B degradation via proteasome
  • critical regulator of TP53-dependent CDKN1A expression in response to multiple TP53-activating stresses
  • selective influence of KAT2B on fear extinction is mediated, in part, by a transient recruitment of the repressive transcription factor ATF4 to the promoter of the immediate early gene EGR2, which competitively inhibits its expression
  • acts as a negative modulator of microtubule stability through acetylation of MAPRE1, a protein that controls the plus ends of microtubules
  • in mitosis, acetylates the mitotic checkpoint protein, BUB1B
  • directly binds to RUNX2 and acetylates RUNX2, leading to an increase in its transcriptional activity
  • EP300 and KAT2B are two TRIM50 acetyltransferases and the balance between ubiquitination and acetylation regulates TRIM50 degradation
  • KAT2B and TADA3 regulate BID processing via PACS2, to modulate the mitochondrial cell death pathway in response to GZMB
  • KAT2A/KAT2B acetylation of PLK4 prevents centrosome amplification
  • cell & other
    inhibited by
  • DEK
  • repressed by
  • DEK
    corresponding disease(s)
    Susceptibility to survival advantage in elderly patients
    Variant & Polymorphism SNP
  • the -2481C allele in the promoter is associated with a significant survival advantage in elderly patients
  • Candidate gene
    Therapy target
    new rationale for therapeutic targeting of KAT2B activity in tumors harboring oncogenic versions of TP53