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FLASH GENE
Symbol TNK1 contributors: - updated : 12-06-2007
HGNC name tyrosine kinase, non-receptor, 1
HGNC id 11940
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal kinase domain
  • a putative SH3 domain
  • a ferm domain
  • a proline-rich C terminal region
    • HOMOLOGY
    Homologene
    FAMILY Ack family of NRPTKs
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • intracellular tyrosine kinase playing a potential role in oncogenic transformations resulting in increased kinase activity
  • playing a role in phospholipid signal transduction
  • playing a negative regulatory role in regulating the Ras-RAF1/MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to late-onset Alzheimer's disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS