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FLASH GENE
Symbol RGS9 contributors: mct/npt - updated : 09-03-2016
HGNC name regulator of G-protein signalling 9
HGNC id 10004
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal DEP (dishevelled/Egl10/pleckstrin) homology domain
  • a GGL domain forming complex with GNB5
  • a RGS homology domain directly responsible for accelerating the GTPase activity of G protein alpha-subunits (Martemyanov 2008)
  • a C terminal region highly enriched in proline and serine residues
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans EGL-10
    homolog to yeast SST2
    homolog to C.elegans c16c2.2
    homolog to murine Rgs9
    Homologene
    FAMILY
  • RGS family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text outer segments
    basic FUNCTION
  • functioning as GTPase activating protein for G proteins alpha i and q subunits
  • underlying the dominant recovery time of (mouse) photoreceptor that a precise level of expression of RGS9 is required for normal photoresponse timing
  • controlling PDE activity through regulation of transducin and inhibiting retinal guanylyl-cyclase
  • RGS9 and SLC24A1 are active in phototransduction in rods and cones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • heterodimer with G beta 5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • G (t)-alpha
  • G beta5
  • R9AP (anchor protein of RGS9)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PERRS
    Susceptibility to antipsychotic-induced tardive dyskinesia in schizophrenia
    Variant & Polymorphism other a significant association of the AGG haplotype (rs8077696-rs8070231-rs2292593) with antipsychotic-induced tardive dyskinesia in schizophrenia (Liou 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    expression diminished in the amphetamine-treated animal model of schizophrenia and in post-mortem schizophrenia brain