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FLASH GENE
Symbol CCNK contributors: npt/mct - updated : 17-10-2018
HGNC name cyclin K
HGNC id 1596
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • possessing both C terminal domain kinase
  • Cdk activating kinase activity
  • HOMOLOGY
    Homologene
    FAMILY
  • cyclin family
  • cyclin C subfamily
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • RNA polymerase II associated cyclin phosphorylating its C-terminal domain also regulating CDK9
  • may play a dual role by regulating CDK and transcription
  • may play a role in regulating the cell cycle or apoptosis after being targeted for transcription by TP53
  • direct role for CDK9–CCNK in checkpoint pathways that maintain genome integrity in response to replication stress
  • mediates the replication stress response functions of CDK9
  • is essential for embryonic stem cell maintenance
  • may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance
  • plays a critical role in transcriptional regulation as well as cell development
  • is thought to play a critical role in the RNA polymerase II-mediated activities
  • is a regulator of neurodevelopment
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text basal transcription
    PATHWAY
    metabolism
    signaling
    a component
  • CDK9–CCNK complex has different biological activities to the CDK9–CCNT1 complex
  • complexing with CDK12
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK9
  • CDK9 and CCNK interact with ataxia telangiectasia and Rad3-related protein and other checkpoint signalling proteins
  • CDK9 binds to cyclin K , and direct role of CDK9-CCNK in pathways that maintain genome integrity in response to replication stress appear to be evolutionarily conserved
  • interaction of CDK12 with CCNK is required for the phosphorylation of the C-terminal domain of RNA polymerase II
  • CDK12/CCNK prefers a substrate with unmodified repeats or one that mimics prephosphorylation at the S7 position of the CTD
  • CCNK-dependent, novel phosphorylation site in cyclin E1 that disrupts its interaction with CDK2
  • cell & other
    REGULATION
    activated by TP53 in response to DNA damage
    ASSOCIATED DISORDERS
    corresponding disease(s) MRSFD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a putative predictive biomarker for clinical outcome and therapy response for patients with prostate cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting CCNK represents a novel, promising anti-cancer strategy to induce cell cycle arrest and apoptotic cell death through induction of mitotic catastrophe in prostate cancer cells
    ANIMAL & CELL MODELS