basic FUNCTION
| may be involved in the formation and progression of glioblastoma multiformis |
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may have a physiologic function connected to the capacity for speech and language |
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coordinates the functional maturation of both pre- and postsynaptic properties during postnatal brain development, and also mediates a structural remodeling of the apical dendrite branches and spines |
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regulated the functional maturation and structural pruning of glutamatergic synapses during postnatal development |
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acts to remodel the hippocampal dentate glutamatergic circuitry |
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regulates postnatal pruning of retinal axons in visual relay thalamus 8) |
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LGI1, LGI2, TSPEAR, ADGRV1 all have indispensable roles only in the peripheral and central auditory system, it is tempting to speculate that they are involved in similar molecular pathways |
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by finely regulating the synaptic AMPA receptors, the LGI1-ADAM22 interaction maintains likely physiological brain excitability throughout life |
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prevents the inactivation of voltage-gated potassium channels, mediates postnatal maturation of glutamatergic synapses, and regulates excitatory neurotransmission |
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is involved in the development of the cerebellum and cortex |